Follow-up testing to confirm H. pylori eradication is necessary after treatment to ensure the infection is gone.

The major determinant of eradication success with PPI-AC is pretreatment clarithromycin resistance.

Patients should always be advised that successful eradication depends on compliance with the treatment. Time should be taken to counsel the patient, explaining how to take the multidrug therapy and anticipating adverse side effects. The need to complete the treatment should be emphasized. Written or pictorial information may also aid compliance.